4NIF

Heterodimeric structure of ERK2 and RSK1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, D)	Ribosomal protein S6 kinase alpha-1	polymer	333	37492.8	2	UniProt (Q15418) Pfam (PF00069)	Homo sapiens (human)	S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, Ribosomal S6 kinase 1, RSK-1
2	B, D (B, E)	Mitogen-activated protein kinase 1	polymer	362	41588.8	2	UniProt (P28482) Pfam (PF00069)	Homo sapiens (human)	MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
3	E, I (B, E)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
4	F, G, J (B, E)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5	H, K (B, E)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6	L, M, N, O (A, B, D, E)	water	water		18.0	1006	Chemie (HOH)

Sequence modifications

A, D: 411 - 735 (UniProt: Q15418)

PDB	External Database	Details
Gly 409	-	expression tag
Ser 410	-	expression tag
His 736	-	expression tag
His 737	-	expression tag
His 738	-	expression tag
His 739	-	expression tag
His 740	-	expression tag
His 741	-	expression tag

B, E: 1 - 360 (UniProt: P28482)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	158163.2
Non-Polymers*	Number of molecules	7
	Total formula weight	1346.6
All*	Total formula weight	159509.7

*Water molecules are not included.