4NGD
Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having 5'-p and UU-3' ends (1.95 Angstrom resolution)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endoribonuclease Dicer | polymer | 302 | 34928.3 | 1 | UniProt (Q9UPY3) Pfam (PF20931) Pfam (PF02170) | Homo sapiens (human) | Helicase with RNase motif, Helicase MOI |
| 2 | B (B) | 5'-R(P*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' | polymer | 12 | 3789.3 | 1 | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 210 | Chemie (HOH) |
Sequence modifications
A: 755 - 1055 (UniProt: Q9UPY3)
| PDB | External Database | Details |
|---|---|---|
| Ser 754 | - | expression tag |
| Ala 822 | Lys 832 | engineered mutation |
| Ala 823 | Lys 833 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38717.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 404.4 | |
| All* | Total formula weight | 39122.0 |
