4NDF

Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn - product complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Aprataxin	polymer	182	21259.8	2	UniProt (Q7Z2E3) Pfam (PF11969) Pfam (PF16278)	Homo sapiens (human)	Forkhead-associated domain histidine triad-like protein, FHA-HIT
2	C, E (D, G)	5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3'	polymer	10	3066.0	2
3	D, F (E, H)	5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'	polymer	10	3037.0	2
4	G, K (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505)
5	H, L (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	I (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA) PubChem (923)
7	J, M (A, B)	BETA-MERCAPTOETHANOL	non-polymer		78.1	2	Chemie (BME)
8	N (E)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K) PubChem (813)
9	O, P, Q, R, S... (A, B, D, E, G...)	water	water		18.0	556	Chemie (HOH)

Sequence modifications

A, B: 165 - 342 (UniProt: Q7Z2E3)

PDB	External Database	Details
Gly 161	-	expression tag
Ser 162	-	expression tag
His 163	-	expression tag
Met 164	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	54725.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1043.6
All*	Total formula weight	55769.2

*Water molecules are not included.