4NDF
Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn - product complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE AMP A 401 |
| Chain | Residue |
| A | LEU171 |
| A | PRO254 |
| A | SER255 |
| A | MET256 |
| A | HIS260 |
| A | HIS262 |
| A | HOH534 |
| A | HOH574 |
| A | HOH578 |
| A | HOH670 |
| A | HOH674 |
| A | SER174 |
| D | G1 |
| A | ASP193 |
| A | LYS194 |
| A | TYR195 |
| A | LYS197 |
| A | HIS201 |
| A | LEU203 |
| A | HIS251 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 402 |
| Chain | Residue |
| A | CYS319 |
| A | CYS322 |
| A | HIS335 |
| A | HIS339 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 403 |
| Chain | Residue |
| A | SER255 |
| A | HOH555 |
| A | HOH629 |
| A | HOH681 |
| D | HOH109 |
| D | HOH116 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME A 404 |
| Chain | Residue |
| A | TYR195 |
| A | CYS272 |
| A | LYS274 |
| A | HOH518 |
| B | GLN298 |
| D | DT3 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE AMP B 401 |
| Chain | Residue |
| B | GLY170 |
| B | LEU171 |
| B | SER174 |
| B | ILE191 |
| B | LYS192 |
| B | ASP193 |
| B | LYS194 |
| B | TYR195 |
| B | LEU203 |
| B | HIS251 |
| B | SER255 |
| B | MET256 |
| B | HIS260 |
| B | HIS262 |
| B | HOH507 |
| B | HOH527 |
| B | HOH535 |
| B | HOH629 |
| B | HOH630 |
| B | HOH631 |
| B | HOH638 |
| B | HOH673 |
| G | G1 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 402 |
| Chain | Residue |
| B | CYS319 |
| B | CYS322 |
| B | HIS335 |
| B | HIS339 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME B 403 |
| Chain | Residue |
| B | TYR195 |
| B | CYS272 |
| B | LYS274 |
| G | DT3 |
| G | HOH103 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K E 101 |
| Chain | Residue |
| D | DT8 |
| D | DT9 |
| E | DT4 |
| E | DC5 |
| E | HOH220 |
| E | HOH221 |
| E | HOH236 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 210 |
| Details | Domain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17276982","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with DNA substrate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Histidine triad motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interaction with DNA substrate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
