4MZ8
Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with an Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound C91
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Inosine-5'-monophosphate dehydrogenase | polymer | 406 | 43524.8 | 4 | UniProt (Q0P9J4) Pfam (PF00478) In PDB | Campylobacter jejuni subsp. jejuni | IMP dehydrogenase, IMPD, IMPDH |
2 | A, D, B, C | INOSINIC ACID | non-polymer | 348.2 | 4 | Chemie (IMP) | |||
3 | A, D, B, C | N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide | non-polymer | 378.4 | 4 | Chemie (C91) | |||
4 | C, A, D, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
5 | A, D, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
6 | A, B | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
7 | A, B | ACETIC ACID | non-polymer | 60.1 | 2 | Chemie (ACY) | |||
8 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
9 | C, A, B | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
10 | A | dimethyl ether | non-polymer | 46.1 | 1 | Chemie (2F2) | |||
11 | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 91 (UniProt: Q0P9J4)
A, B, C, D: 196 - 485 (UniProt: Q0P9J4)
PDB | External Database | Details |
---|---|---|
Met -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
Ser -16 | - | expression tag |
Ser -15 | - | expression tag |
Gly -14 | - | expression tag |
Val -13 | - | expression tag |
Asp -12 | - | expression tag |
Leu -11 | - | expression tag |
Gly -10 | - | expression tag |
Thr -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Ser -2 | - | expression tag |
Asn -1 | - | expression tag |
Ala 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 92 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 174099.3 | |
Non-Polymers* | Number of molecules | 31 |
Total formula weight | 4473.0 | |
All* | Total formula weight | 178572.3 |