Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0003938 | molecular_function | IMP dehydrogenase activity |
A | 0006164 | biological_process | purine nucleotide biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0003938 | molecular_function | IMP dehydrogenase activity |
B | 0006164 | biological_process | purine nucleotide biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0003938 | molecular_function | IMP dehydrogenase activity |
C | 0006164 | biological_process | purine nucleotide biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0003938 | molecular_function | IMP dehydrogenase activity |
D | 0006164 | biological_process | purine nucleotide biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE IMP A 501 |
Chain | Residue |
A | ALA46 |
A | GLY336 |
A | MET355 |
A | GLY357 |
A | SER358 |
A | TYR381 |
A | GLY383 |
A | MET384 |
A | GLY385 |
A | GLU411 |
A | GLY412 |
A | MET48 |
A | C91502 |
A | HOH610 |
A | HOH625 |
A | HOH646 |
A | HOH680 |
A | HOH681 |
A | ASN273 |
A | GLY298 |
A | SER299 |
A | ILE300 |
A | CYS301 |
A | ASP334 |
A | GLY335 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE C91 A 502 |
Chain | Residue |
A | ALA246 |
A | THR303 |
A | MET384 |
A | GLY385 |
A | MET390 |
A | LEU408 |
A | GLU411 |
A | IMP501 |
B | GLY439 |
B | TYR440 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 503 |
Chain | Residue |
A | TYR378 |
A | ARG416 |
A | HOH695 |
B | THR472 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 504 |
Chain | Residue |
A | SER422 |
A | ARG424 |
A | HOH635 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE FMT A 505 |
Chain | Residue |
A | GLN226 |
A | ARG229 |
A | HOH668 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACY A 506 |
Chain | Residue |
A | ILE29 |
A | ASN40 |
A | ASP207 |
A | ARG435 |
A | HOH662 |
A | HOH665 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 507 |
Chain | Residue |
A | ARG62 |
A | SER88 |
A | GLU89 |
A | LYS210 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 508 |
Chain | Residue |
A | THR460 |
A | THR460 |
B | THR460 |
B | THR460 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE 2F2 A 509 |
Chain | Residue |
A | TYR373 |
A | GLN374 |
D | TYR373 |
D | GLN374 |
site_id | BC1 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE IMP B 501 |
Chain | Residue |
B | ALA46 |
B | MET48 |
B | ASN273 |
B | GLY298 |
B | SER299 |
B | ILE300 |
B | CYS301 |
B | ASP334 |
B | GLY335 |
B | GLY336 |
B | MET355 |
B | GLY357 |
B | SER358 |
B | TYR381 |
B | GLY383 |
B | MET384 |
B | GLY385 |
B | GLU411 |
B | GLY412 |
B | C91502 |
B | ACY506 |
B | HOH615 |
B | HOH623 |
B | HOH627 |
B | HOH685 |
B | HOH689 |
site_id | BC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE C91 B 502 |
Chain | Residue |
B | ACY506 |
B | EDO509 |
A | SER436 |
A | GLY439 |
A | TYR440 |
B | ALA246 |
B | THR303 |
B | GLY385 |
B | MET390 |
B | LEU408 |
B | GLU411 |
B | IMP501 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 503 |
Chain | Residue |
A | THR472 |
B | TYR378 |
B | ARG416 |
site_id | BC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL B 504 |
site_id | BC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 B 505 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACY B 506 |
Chain | Residue |
B | ASP244 |
B | SER245 |
B | ASN273 |
B | IMP501 |
B | C91502 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 507 |
Chain | Residue |
B | PHE371 |
B | TYR373 |
B | ARG416 |
C | TYR373 |
C | ARG416 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 508 |
Chain | Residue |
B | TYR373 |
B | GLN374 |
B | ARG416 |
C | TYR373 |
C | GLN374 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 509 |
Chain | Residue |
B | SER245 |
B | ALA246 |
B | C91502 |
B | HOH620 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE FMT B 510 |
Chain | Residue |
B | GLN226 |
B | ARG229 |
B | HOH672 |
site_id | CC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 511 |
Chain | Residue |
B | SER422 |
B | ARG424 |
B | HOH622 |
site_id | CC3 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE IMP C 501 |
Chain | Residue |
C | ALA46 |
C | MET48 |
C | ASN273 |
C | GLY298 |
C | SER299 |
C | ILE300 |
C | CYS301 |
C | ASP334 |
C | GLY335 |
C | GLY336 |
C | MET355 |
C | GLY357 |
C | SER358 |
C | TYR381 |
C | GLY383 |
C | MET384 |
C | GLY385 |
C | GLU411 |
C | GLY412 |
C | C91502 |
C | HOH610 |
C | HOH623 |
C | HOH630 |
C | HOH643 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE C91 C 502 |
Chain | Residue |
C | ALA246 |
C | HIS247 |
C | MET390 |
C | GLU411 |
C | IMP501 |
D | PRO24 |
D | GLY439 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 503 |
Chain | Residue |
C | ARG376 |
C | TYR378 |
C | ARG416 |
D | THR472 |
site_id | CC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL C 504 |
site_id | CC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL C 505 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 506 |
Chain | Residue |
C | SER422 |
C | ARG424 |
C | HOH642 |
C | HOH646 |
site_id | CC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 507 |
Chain | Residue |
C | THR460 |
C | THR460 |
D | THR460 |
site_id | DC1 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE IMP D 501 |
Chain | Residue |
D | ALA46 |
D | MET48 |
D | GLY298 |
D | SER299 |
D | ILE300 |
D | CYS301 |
D | ASP334 |
D | GLY335 |
D | GLY336 |
D | GLY357 |
D | SER358 |
D | TYR381 |
D | GLY383 |
D | MET384 |
D | GLY385 |
D | GLU411 |
D | GLY412 |
D | C91502 |
D | HOH604 |
site_id | DC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE C91 D 502 |
Chain | Residue |
C | GLY439 |
C | TYR440 |
D | ALA246 |
D | THR303 |
D | GLY385 |
D | MET390 |
D | GLU411 |
D | IMP501 |
site_id | DC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 D 503 |
Chain | Residue |
C | THR472 |
D | TYR378 |
D | ARG416 |
site_id | DC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL D 504 |
Chain | Residue |
D | SER422 |
D | ARG424 |
D | SER425 |
Functional Information from PROSITE/UniProt
site_id | PS00487 |
Number of Residues | 13 |
Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGIGpGSICtT |
Chain | Residue | Details |
A | VAL291-THR303 | |