4MMS
Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 5.5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Fusion glycoprotein F2 | polymer | 82 | 9215.4 | 3 | UniProt (P03420) | Human respiratory syncytial virus A2 | |
| 2 | B, D, F (B, D, F) | Fusion glycoprotein F1 fused with Fibritin trimerization domain | polymer | 414 | 45577.0 | 3 | UniProt (P03420) UniProt (P10104) Pfam (PF00523) | Human respiratory syncytial virus A2 | |
| 3 | G, H, I, J, K... (B, D, F) | SULFATE ION | non-polymer | 96.1 | 14 | Chemie (SO4) | |||
| 4 | U, V, W, X, Y... (A, B, C, D, E...) | water | water | 18.0 | 522 | Chemie (HOH) |
Sequence modifications
A, C, E: 26 - 107 (UniProt: P03420)
B, D, F: 137 - 513 (UniProt: P03420)
B, D, F: 518 - 544 (UniProt: P10104)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Pro 102 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Phe 190 | Ser 190 | engineered mutation |
| Leu 207 | Val 207 | engineered mutation |
| Val 379 | Ile 379 | engineered mutation |
| Val 447 | Met 447 | engineered mutation |
| Ser 514 | - | linker |
| Ala 515 | - | linker |
| Ile 516 | - | linker |
| Gly 517 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 539 | Phe 479 | variant |
| Gly 545 | - | expression tag |
| Gly 546 | - | expression tag |
| Leu 547 | - | expression tag |
| Val 548 | - | expression tag |
| Pro 549 | - | expression tag |
| Arg 550 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 164377.3 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1344.9 | |
| All* | Total formula weight | 165722.2 |
