4MLB

Reverse polarity of binding pocket suggests different function of a MOP superfamily transporter from Pyrococcus furiosus Vc1 (DSM3638)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	PF0708	polymer	492	52928.1	4	UniProt (Q8U2X0) Pfam (PF01554)	Pyrococcus furiosus
2	AA, AB, BA, BB, CA... (B, D, A, C)	PENTAETHYLENE GLYCOL MONODECYL ETHER	non-polymer		378.5	53	Chemie (CXE)
3	V, W (A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	HB, IB, JB, KB (A, B, C, D)	water	water		18.0	327	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 461 (UniProt: Q8U2X0)

PDB	External Database	Details
Met -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Glu -2	-	expression tag
Ile -1	-	expression tag
Pro 0	-	expression tag
Thr 298	Ala 298	conflict
Arg 462	-	expression tag
Asn 463	-	expression tag
Ser 464	-	expression tag
Glu 465	-	expression tag
Asn 466	-	expression tag
Leu 467	-	expression tag
Tyr 468	-	expression tag
Phe 469	-	expression tag
Gln 470	-	expression tag
Gly 471	-	expression tag
Gly 472	-	expression tag
Arg 473	-	expression tag
Gly 474	-	expression tag
Ser 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag
His 482	-	expression tag
His 483	-	expression tag
His 484	-	expression tag
His 485	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	211712.5
Non-Polymers*	Number of molecules	55
	Total formula weight	20133.7
All*	Total formula weight	231846.3

*Water molecules are not included.