Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4MLB

Reverse polarity of binding pocket suggests different function of a MOP superfamily transporter from Pyrococcus furiosus Vc1 (DSM3638)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0015297	molecular_function	antiporter activity
A	0016020	cellular_component	membrane
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0015297	molecular_function	antiporter activity
B	0016020	cellular_component	membrane
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0015297	molecular_function	antiporter activity
C	0016020	cellular_component	membrane
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0055085	biological_process	transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0015297	molecular_function	antiporter activity
D	0016020	cellular_component	membrane
D	0042908	biological_process	xenobiotic transport
D	0042910	molecular_function	xenobiotic transmembrane transporter activity
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CXE A 501

Chain	Residue
A	LYS7
A	ASP165
A	ASN167
A	CXE506
A	CXE515
A	HOH651
B	TRP44

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CXE A 502

Chain	Residue
A	TYR189
A	THR190
B	LEU171
B	VAL174
B	CXE503
A	ILE181
A	PRO185

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CXE A 503

Chain	Residue
A	TYR322
A	CXE509
B	CXE506

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CXE A 504

Chain	Residue
A	LEU101
A	PHE218
A	ILE227
A	LEU229
A	CXE517
A	HOH665
D	THR190
D	LEU191

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE A 505

Chain	Residue
A	TYR347
B	CXE511

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CXE A 506

Chain	Residue
A	LEU171
A	VAL174
A	LEU175
A	TRP216
A	CXE501
B	ILE181
B	PRO185
B	TYR189
B	THR190

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CXE A 507

Chain	Residue
A	PHE378

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CXE A 508

Chain	Residue
A	PHE341
A	GLN344
D	LYS453

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CXE A 509

Chain	Residue
A	SER32
A	LEU288
A	CXE503
B	LEU36

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CXE A 510

Chain	Residue
A	LEU69

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CXE A 511

Chain	Residue
A	ALA145
A	PHE148
C	CXE513

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CXE A 512

Chain	Residue
A	SER210

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CXE A 513

Chain	Residue
A	MET64
A	LEU69
A	SER250
A	SER257

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CXE A 515

Chain	Residue
A	CXE501

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CXE A 516

Chain	Residue
A	PHE218
A	CXE517
C	MET329
C	CXE514
D	THR190

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CXE A 517

Chain	Residue
A	CXE504
A	CXE516
C	CXE505

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 518

Chain	Residue
A	TRP216
A	HOH652
A	HOH671
B	THR190

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 519

Chain	Residue
A	THR190
B	TRP216

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CXE B 501

Chain	Residue
A	THR190
A	LEU191
B	TYR215
C	LEU39
C	ILE43
D	LYS4

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CXE B 502

Chain	Residue
B	THR190
B	LEU191
B	GLY192
C	VAL21
C	CXE505

site_id	CC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CXE B 503

Chain	Residue
A	TRP44
A	CXE502
B	LYS7
B	GLY8
B	LEU11
B	ASP165
B	ASN167
B	ARG168
B	CXE509

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE B 504

Chain	Residue
B	LEU101
B	CXE510

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CXE B 505

Chain	Residue
B	THR110

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CXE B 506

Chain	Residue
A	CXE503
B	PHE337
B	GLN344

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CXE B 507

Chain	Residue
B	LEU73
B	GLY246
B	SER250

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE B 509

Chain	Residue
B	ILE29
B	CXE503

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE B 510

Chain	Residue
B	LEU229
B	CXE504

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE B 511

Chain	Residue
A	CXE505
B	ILE25

site_id	DC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CXE B 512

Chain	Residue
B	THR114

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CXE C 501

Chain	Residue
B	VAL109
B	ILE113
C	VAL208
C	PHE212
C	TYR215
C	VAL219
C	CXE503

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CXE C 502

Chain	Residue
A	LEU442
A	HOH633
C	LEU229
C	ARG230
C	ASP231

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CXE C 503

Chain	Residue
B	ILE113
C	SER210
C	LEU211
C	ALA214
C	CXE501

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CXE C 504

Chain	Residue
C	GLU391
C	LYS394
C	ARG447
C	CXE515
C	HOH613
D	CXE501

site_id	DC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CXE C 505

Chain	Residue
A	CXE517
B	CXE502
C	TYR322
C	ILE326
C	MET329
C	CXE514
C	HOH699

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CXE C 506

Chain	Residue
C	LEU101
C	ARG221
C	ILE227
C	THR228
C	LEU229
C	CXE516

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE C 507

Chain	Residue
C	LEU404
D	CXE504

site_id	EC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE C 508

Chain	Residue
C	PHE410
D	CXE505

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE C 509

Chain	Residue
C	GLY192
C	PHE193

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE C 510

Chain	Residue
A	TYR417
C	ALA145

site_id	EC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CXE C 511

Chain	Residue
C	PRO61
C	GLY65
C	LEU69
C	LEU247
C	SER250
C	LEU254
C	SER257

site_id	EC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CXE C 512

Chain	Residue
C	TYR37
C	ASN38
C	PHE63
C	ALA172
C	GLY176
C	ASN180
C	THR202
C	THR209

site_id	EC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CXE C 513

Chain	Residue
A	ARG141
A	VAL142
A	ALA145
A	PHE193
A	TYR200
A	CXE511
C	LEU340
C	PHE341
C	PRO343
C	GLN344
C	TYR347
C	LEU348
C	LYS359

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CXE C 514

Chain	Residue
A	CXE516
C	LEU321
C	LYS325
C	CXE505
D	TYR189

site_id	EC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CXE C 515

Chain	Residue
C	CXE504

site_id	EC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE C 516

Chain	Residue
C	PHE218
C	CXE506

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CXE D 501

Chain	Residue
C	VAL439
C	TRP443
C	CXE504
D	TYR347

site_id	FC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CXE D 502

Chain	Residue
B	VAL374
B	LEU375
B	MET434
D	GLU393
D	LYS394
D	TRP443

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CXE D 503

Chain	Residue
C	TYR417
D	ILE25
D	MET28
D	SER32
D	CXE505

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CXE D 504

Chain	Residue
C	CXE507
D	PHE337

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CXE D 505

Chain	Residue
C	CXE508
D	MET329
D	CXE503

site_id	FC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CXE D 506

Chain	Residue
D	PHE212

site_id	FC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CXE D 507

Chain	Residue
C	PHE441
D	TRP44
D	TYR189

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)