4LGD
Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Serine/threonine-protein kinase 3 | polymer | 378 | 43626.2 | 4 | UniProt (Q13188) Pfam (PF00069) Pfam (PF11629) In PDB | Homo sapiens (human) | Mammalian STE20-like protein kinase 2, MST-2, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3 36kDa subunit, MST2/N, Serine/threonine-protein kinase 3 20kDa subunit, MST2/C |
2 | E, F, G, H | Ras association domain family member 5, RASSF5 | polymer | 49 | 5963.7 | 4 | UniProt (Q8WWW0) Pfam (PF16517) In PDB | Homo sapiens (human) | New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL |
3 | A, B, C, D | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 4 | Chemie (ANP) | |||
4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | D, A, B, C | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
6 | D, C | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) |
Sequence modifications
A, B, C, D: 9 - 313 (UniProt: Q13188)
A, B, C, D: 428 - 491 (UniProt: Q13188)
PDB | External Database | Details |
---|---|---|
Met 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
Gly 7 | - | expression tag |
Ser 8 | - | expression tag |
Asn 146 | Asp 146 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 198359.3 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 3055.5 | |
All* | Total formula weight | 201414.8 |