4LG8

Crystal structure of PRPF19 WD40 repeats

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Pre-mRNA-processing factor 19	polymer	354	39059.9	1	UniProt (Q9UMS4) Pfam (PF00400)	Homo sapiens (human)	Nuclear matrix protein 200, PRP19/PSO4 homolog, hPso4, Senescence evasion factor
2	B, C (A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
3	D, E, F, G, H... (A)	UNKNOWN ATOM OR ION	non-polymer			14	Chemie (UNX)
4	R (A)	water	water		18.0	135	Chemie (HOH)

Sequence modifications

A: 169 - 504 (UniProt: Q9UMS4)

PDB	External Database	Details
Met 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag
His 155	-	expression tag
His 156	-	expression tag
His 157	-	expression tag
Ser 158	-	expression tag
Ser 159	-	expression tag
Gly 160	-	expression tag
Arg 161	-	expression tag
Glu 162	-	expression tag
Asn 163	-	expression tag
Leu 164	-	expression tag
Tyr 165	-	expression tag
Phe 166	-	expression tag
Gln 167	-	expression tag
Gly 168	-	expression tag
Glu 189	Lys 189	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	39059.9
Non-Polymers*	Number of molecules	16
	Total formula weight	46.0
All*	Total formula weight	39105.9

*Water molecules are not included.