4LG8

Crystal structure of PRPF19 WD40 repeats

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000974	cellular_component	Prp19 complex
A	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 601

Chain	Residue
A	ASP412
A	SER414
A	ASN434
A	HOH701
A	HOH702
A	HOH703

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 602

Chain	Residue
A	HOH726
A	HOH809
A	GLN300
A	THR337
A	THR472

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Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAadDsSVKLWDL

Chain	Residue	Details
A	LEU407-LEU421

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	41
Details	Repeat: {"description":"WD 3"}

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Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	39
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	30
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99KP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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