4LG8

Crystal structure of PRPF19 WD40 repeats

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000974	cellular_component	Prp19 complex
A	0006281	biological_process	DNA repair
A	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 601

Chain	Residue
A	ASP412
A	SER414
A	ASN434
A	HOH701
A	HOH702
A	HOH703

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 602

Chain	Residue
A	HOH726
A	HOH809
A	GLN300
A	THR337
A	THR472

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Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAadDsSVKLWDL

Chain	Residue	Details
A	LEU407-LEU421

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99KP6

Chain	Residue	Details
A	LYS179
A	LYS244

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS261

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