4LC9

Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glucokinase regulatory protein	polymer	636	70152.5	1	UniProt (Q07071) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741) In PDB	Rattus norvegicus (brown rat rat rats)	Glucokinase regulator
2	B	Glucokinase	polymer	472	53204.5	1	UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB	Homo sapiens (human)	Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D
3	A	6-O-phosphono-beta-D-fructofuranose	non-polymer		260.1	1	Chemie (F6P)
4	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)

Sequence modifications

A: 1 - 627 (UniProt: Q07071)

PDB	External Database	Details
Ser 628	-	expression tag
Leu 629	-	expression tag
Glu 630	-	expression tag
His 631	-	expression tag
His 632	-	expression tag
His 633	-	expression tag
His 634	-	expression tag
His 635	-	expression tag
His 636	-	expression tag

B: 3 - 465 (UniProt: P35557)

PDB	External Database	Details
Met -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Met 1	-	expression tag
Val 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	123356.9
Non-Polymers*	Number of molecules	2
	Total formula weight	283.1
All*	Total formula weight	123640.0

*Water molecules are not included.