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4LC9

Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0001678biological_processintracellular glucose homeostasis
A0004857molecular_functionenzyme inhibitor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006606biological_processprotein import into nucleus
A0009749biological_processresponse to glucose
A0009750biological_processresponse to fructose
A0019210molecular_functionkinase inhibitor activity
A0019899molecular_functionenzyme binding
A0019900molecular_functionkinase binding
A0019904molecular_functionprotein domain specific binding
A0030246molecular_functioncarbohydrate binding
A0034504biological_processprotein localization to nucleus
A0042593biological_processglucose homeostasis
A0046415biological_processurate metabolic process
A0070095molecular_functionfructose-6-phosphate binding
A0070328biological_processtriglyceride homeostasis
A0097367molecular_functioncarbohydrate derivative binding
A0141089molecular_functionglucose sensor activity
A1901135biological_processcarbohydrate derivative metabolic process
B0001678biological_processintracellular glucose homeostasis
B0004340molecular_functionglucokinase activity
B0004396molecular_functionhexokinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005536molecular_functionD-glucose binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0006006biological_processglucose metabolic process
B0006007biological_processglucose catabolic process
B0006096biological_processglycolytic process
B0006110biological_processregulation of glycolytic process
B0006739biological_processNADP metabolic process
B0008865molecular_functionfructokinase activity
B0009749biological_processresponse to glucose
B0016301molecular_functionkinase activity
B0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
B0019158molecular_functionmannokinase activity
B0019318biological_processhexose metabolic process
B0032024biological_processpositive regulation of insulin secretion
B0032869biological_processcellular response to insulin stimulus
B0042593biological_processglucose homeostasis
B0043266biological_processregulation of potassium ion transport
B0044320biological_processcellular response to leptin stimulus
B0045721biological_processnegative regulation of gluconeogenesis
B0045725biological_processpositive regulation of glycogen biosynthetic process
B0046835biological_processcarbohydrate phosphorylation
B0050796biological_processregulation of insulin secretion
B0051156biological_processglucose 6-phosphate metabolic process
B0061621biological_processcanonical glycolysis
B0070509biological_processcalcium ion import
B0141089molecular_functionglucose sensor activity
B1901135biological_processcarbohydrate derivative metabolic process
Functional Information from PROSITE/UniProt
site_idPS00378
Number of Residues26
DetailsHEXOKINASE_1 Hexokinase domain signature. LGFTFSFPvrhedIDkgiLlnWTKgF
ChainResidueDetails
BLEU146-PHE171

site_idPS01272
Number of Residues18
DetailsGCKR Glucokinase regulatory protein family signature. GPEgLSGSSRMKGGGatK
ChainResidueDetails
AGLY250-LYS267

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P19367
ChainResidueDetails
BASP78
ASER179
ALYS514

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:15016359
ChainResidueDetails
BSER151
BTHR168
BASN204
BASN231
BGLU256
BGLU290

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:22101819, ECO:0007744|PDB:3FGU, ECO:0007744|PDB:3ID8
ChainResidueDetails
BTHR228
BGLY295
BTHR332
BSER411

Catalytic Information from CSA
site_idMCSA1
Number of Residues2
DetailsM-CSA 592
ChainResidueDetails
BLYS169proton acceptor, proton donor
BASP205metal ligand, proton acceptor, proton donor

223532

PDB entries from 2024-08-07

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