4L8R

Structure of mrna stem-loop, human stem-loop binding protein and 3'hexo ternary complex

Replaces:  4HXH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	HISTONE MRNA STEM-LOOP	polymer	26	8223.0	2
2	B, E (B, E)	3'-5' exoribonuclease 1	polymer	303	35815.6	2	UniProt (Q8IV48) Pfam (PF02037) Pfam (PF00929)	Homo sapiens (human)	3'-5' exonuclease ERI1, Eri-1 homolog, Histone mRNA 3'-end-specific exoribonuclease, Histone mRNA 3'-exonuclease 1, Protein 3'hExo, HEXO
3	C (C)	Histone RNA hairpin-binding protein	polymer	120	14072.8	1	UniProt (Q14493) Pfam (PF15247)	Homo sapiens (human)	Histone stem-loop-binding protein
4	F, G, H, I, J (A, B, C, D, E)	water	water		18.0	135	Chemie (HOH)

Sequence modifications

B, E: 55 - 349 (UniProt: Q8IV48)

PDB	External Database	Details
Leu 350	-	expression tag
Glu 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag
His 355	-	expression tag
His 356	-	expression tag
His 357	-	expression tag

C: 125 - 223 (UniProt: Q14493)

PDB	External Database	Details
Met 104	-	expression tag
Gly 105	-	expression tag
Ser 106	-	expression tag
Ser 107	-	expression tag
His 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
Ser 114	-	expression tag
Ser 115	-	expression tag
Gly 116	-	expression tag
Leu 117	-	expression tag
Val 118	-	expression tag
Pro 119	-	expression tag
Arg 120	-	expression tag
Gly 121	-	expression tag
Ser 122	-	expression tag
His 123	-	expression tag
Met 124	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	102150.0
All*	Total formula weight	102150.0

*Water molecules are not included.