4L8R

Structure of mrna stem-loop, human stem-loop binding protein and 3'hexo ternary complex

Replaces:  4HXH

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
E	0000175	molecular_function	3'-5'-RNA exonuclease activity
E	0003676	molecular_function	nucleic acid binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:22439849, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	THR171
B	HIS293
E	GLU136
E	HIS293

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
C	SER182
E	ASP234
E	HIS293
E	ASP298
B	GLU136
B	ALA137
B	ASP234
B	HIS293
B	ASP298
E	ASP134
E	GLU136
E	ALA137

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER59
E	SER59

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER62
E	SER62

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 784

Chain	Residue	Details
B	ASP134	metal ligand
B	GLU136	electrostatic stabiliser, metal ligand, proton acceptor
B	ASP234	metal ligand
B	HIS293	electrostatic stabiliser, proton acceptor
B	ASP298	metal ligand

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site_id	MCSA2
Number of Residues	5
Details	M-CSA 784

Chain	Residue	Details
E	ASP134	metal ligand
E	GLU136	electrostatic stabiliser, metal ligand, proton acceptor
E	ASP234	metal ligand
E	HIS293	electrostatic stabiliser, proton acceptor
E	ASP298	metal ligand

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