4L8R

Structure of mrna stem-loop, human stem-loop binding protein and 3'hexo ternary complex

Replaces:  4HXH

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
E	0000175	molecular_function	3'-5'-RNA exonuclease activity
E	0003676	molecular_function	nucleic acid binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15451662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W0H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15451662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W0H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"22439849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 784

Chain	Residue	Details
B	GLY142	metal ligand
B	PRO144	electrostatic stabiliser, metal ligand, proton acceptor
B	SER246	metal ligand
B	ARG317	electrostatic stabiliser, proton acceptor
B	MSE322	metal ligand

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 784

Chain	Residue	Details
E	GLY142	metal ligand
E	PRO144	electrostatic stabiliser, metal ligand, proton acceptor
E	SER246	metal ligand
E	ARG317	electrostatic stabiliser, proton acceptor
E	MSE322	metal ligand

---