4KRS
Tankyrase-1 complexed with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tankyrase-1 | polymer | 223 | 25352.7 | 2 | UniProt (O95271) Pfam (PF00644) | Homo sapiens (human) | TANK1, ADP-ribosyltransferase diphtheria toxin-like 5, ARTD5, Poly [ADP-ribose] polymerase 5A, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I |
| 2 | C, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, F, G, J (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | H, K (A, B) | 4-tert-butyl-N-(5,6-dihydro[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)benzamide | non-polymer | 302.4 | 2 | Chemie (1SX) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B: 1105 - 1327 (UniProt: O95271)
| PDB | External Database | Details |
|---|---|---|
| Ile 1266 | Met 1266 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50705.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1215.9 | |
| All* | Total formula weight | 51921.2 |
