4KRP
Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 625 | 69299.8 | 1 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (B) | Nanobody/VHH domain 9G8 | polymer | 136 | 15183.6 | 1 | Lama glama (llama) | ||
| 3 | C (C) | Cetuximab light chain | polymer | 211 | 23159.6 | 1 | Mus musculus Homo sapiens (mouse human) | ||
| 4 | D (D) | Cetuximab heavy chain | polymer | 220 | 23638.4 | 1 | Mus musculus Homo sapiens (mouse human) | ||
| 5 | E, F (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | G, H, I, J (A, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 7 | K, L, M (A, C, D) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 1 - 619 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Thr 614 | - | expression tag |
| His 620 | - | expression tag |
| His 621 | - | expression tag |
| His 622 | - | expression tag |
| His 623 | - | expression tag |
| His 624 | - | expression tag |
| His 625 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 131281.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 133015.1 |
