4KRP

Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Epidermal growth factor receptor	polymer	625	69299.8	1	UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB	Homo sapiens (human)	Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
2	B	Nanobody/VHH domain 9G8	polymer	136	15183.6	1		Lama glama (llama)
3	C	Cetuximab light chain	polymer	211	23159.6	1		Mus musculus Homo sapiens (mouse human)
4	D	Cetuximab heavy chain	polymer	220	23638.4	1		Mus musculus Homo sapiens (mouse human)
5	E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	A, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7		water	water		18.0	3	Chemie (HOH)

Sequence modifications

A: 1 - 619 (UniProt: P00533)

PDB	External Database	Details
Thr 614	-	expression tag
His 620	-	expression tag
His 621	-	expression tag
His 622	-	expression tag
His 623	-	expression tag
His 624	-	expression tag
His 625	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131281.5
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	133015.1

*Water molecules are not included.