4KQ8
Structure of Recombinant Human Cytochrome P450 Aromatase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450 19A1 | polymer | 473 | 54685.9 | 1 | UniProt (P11511) Pfam (PF00067) | Homo sapiens (human) | Aromatase, CYPXIX, Cytochrome P-450AROM, Estrogen synthase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | 4-ANDROSTENE-3-17-DIONE | non-polymer | 286.4 | 1 | Chemie (ASD) PubChem (16401731) PubChem (2193) PubChem (6128) PubChem (45038166) PubChem (45157398) PubChem (45358828) PubChem (51571550) PubChem (1777655) PubChem (1777653) PubChem (1777654) PubChem (249335) PubChem (68200178) PubChem (70987809) PubChem (86310158) PubChem (86310317) PubChem (90350327) PubChem (712379) PubChem (719687) PubChem (6432604) PubChem (6603719) PubChem (118179606) PubChem (7059480) PubChem (7092858) PubChem (7092862) PubChem (121467525) PubChem (11869385) PubChem (12502771) PubChem (10636976) PubChem (124306669) PubChem (11862468) PubChem (11869386) PubChem (12502775) PubChem (12502776) PubChem (124905398) PubChem (139408315) PubChem (141834009) PubChem (142980352) PubChem (144685561) PubChem (144685562) PubChem (163076809) | |||
| 4 | D (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 5 | E (A) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 45 - 503 (UniProt: P11511)
| PDB | External Database | Details |
|---|---|---|
| Met 35 | - | expression tag |
| Ala 36 | - | expression tag |
| Lys 37 | - | expression tag |
| Lys 38 | - | expression tag |
| Thr 39 | - | expression tag |
| Ser 40 | - | expression tag |
| Ser 41 | - | expression tag |
| Lys 42 | - | expression tag |
| Gly 43 | - | expression tag |
| Arg 44 | - | expression tag |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54685.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 997.9 | |
| All* | Total formula weight | 55683.8 |
