4KQ8

Structure of Recombinant Human Cytochrome P450 Aromatase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002677	biological_process	negative regulation of chronic inflammatory response
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006703	biological_process	estrogen biosynthetic process
A	0006710	biological_process	androgen catabolic process
A	0006949	biological_process	syncytium formation
A	0008209	biological_process	androgen metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0008585	biological_process	female gonad development
A	0009055	molecular_function	electron transfer activity
A	0010760	biological_process	negative regulation of macrophage chemotaxis
A	0016020	cellular_component	membrane
A	0016125	biological_process	sterol metabolic process
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030540	biological_process	female genitalia development
A	0030879	biological_process	mammary gland development
A	0032355	biological_process	response to estradiol
A	0046872	molecular_function	metal ion binding
A	0060065	biological_process	uterus development
A	0060736	biological_process	prostate gland growth
A	0061370	biological_process	testosterone biosynthetic process
A	0070330	molecular_function	aromatase activity
A	2000866	biological_process	positive regulation of estradiol secretion

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM A 601

Chain	Residue
A	ARG115
A	ARG375
A	PRO429
A	PHE430
A	GLY431
A	ARG435
A	GLY436
A	CYS437
A	MET446
A	MET447
A	ASD602
A	ILE132
A	TRP141
A	ARG145
A	LEU152
A	ALA306
A	MET311
A	MET364
A	VAL373

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ASD A 602

Chain	Residue
A	ARG115
A	ILE133
A	TRP224
A	ALA306
A	ASP309
A	THR310
A	VAL370
A	LEU372
A	MET374
A	LEU477
A	HEM601

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 603

Chain	Residue
A	HIS109
A	ASN110
A	HIS111
A	HOH702

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGPRGCAG

Chain	Residue	Details
A	PHE430-GLY439

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	MET303-ALA323

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	ASP309
A	MET374

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:19129847, ECO:0007744|PDB:3EQM

Chain	Residue	Details
A	CYS437

---