4KMN
Structure of cIAP1-BIR3 and inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Baculoviral IAP repeat-containing protein 2 | polymer | 103 | 11822.4 | 1 | UniProt (Q13490) Pfam (PF00653) In PDB | Homo sapiens (human) | C-IAP1, IAP homolog B, Inhibitor of apoptosis protein 2, IAP-2, hIAP-2, hIAP2, RING finger protein 48, TNFR2-TRAF-signaling complex protein 2 |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | (2S)-N-{(2R)-1-[(2R,4S)-2-{[6,6'-difluoro-3'-({(2R,4S)-4-hydroxy-1-[(2S)-2-{[(2S)-2-(methylamino)propanoyl]amino}butanoyl]pyrrolidin-2-yl}methyl)-1H,1'H-2,2'-biindol-3-yl]methyl}-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl}-2-(methylamino)propanamide | non-polymer | 806.9 | 1 | Chemie (436) | |||
| 4 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A: 254 - 351 (UniProt: Q13490)
| PDB | External Database | Details |
|---|---|---|
| Ala 251 | - | expression tag |
| Ala 252 | - | expression tag |
| Ala 253 | - | expression tag |
| Ala 352 | - | expression tag |
| Ala 353 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11822.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 967.3 | |
| All* | Total formula weight | 12789.7 |
