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4KFB

HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site

Replaces:  4I7G
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
REVERSE TRANSCRIPTASE/RIBONUCLEASE H, EXORIBONUCLEA P66 RTpolymer55763989.21UniProt (P03366)
Pfam (PF00078)
Pfam (PF06817)
Pfam (PF06815)
Pfam (PF00075)
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)GAG-POL POLYPROTEIN
2B
(B)
P51 RTpolymer42950096.51UniProt (P03366)
Pfam (PF00078)
Pfam (PF06817)
Pfam (PF06815)
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)Gag-Pol polyprotein
3C
(A)
ethyl pyrazolo[1,5-a]pyridine-3-carboxylatenon-polymer190.21Chemie (1QP)
4D, E, F, G, H...
(A, B)
DIMETHYL SULFOXIDEnon-polymer78.110Chemie (DMS)
5I
(A)
4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrilenon-polymer366.41Chemie (T27)
6O, P
(A, B)
waterwater18.0659Chemie (HOH)
Sequence modifications
A: 1 - 555 (UniProt: P03366)
PDBExternal DatabaseDetails
Met -1-expression tag
Val 0-expression tag
Ala 172Lys 771engineered mutation
Ala 173Lys 772engineered mutation
Ser 280Cys 879engineered mutation
B: 5 - 416 (UniProt: P03366)
PDBExternal DatabaseDetails
Gly 0-expression tag
Pro 1-expression tag
Ile 2-expression tag
Ser 3-expression tag
Pro 4-expression tag
Ser 268Cys 879engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight114085.8
Non-Polymers*Number of molecules12
Total formula weight1337.9
All*Total formula weight115423.7
*Water molecules are not included.

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PDB entries from 2024-11-13

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