4KBZ
Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetylamino}-phenyl-acetic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Egl nine homolog 1 | polymer | 238 | 26681.4 | 1 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | Homo sapiens (human) | Hypoxia-inducible factor prolyl hydroxylase 2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20 |
| 2 | A | (2S)-({[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetyl}amino)(phenyl)ethanoic acid | non-polymer | 394.4 | 1 | Chemie (1QA) | |||
| 3 | A | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 184 - 419 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 182 | - | expression tag |
| Ser 183 | - | expression tag |
| Leu 410 | Val 410 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26681.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 738.4 | |
| All* | Total formula weight | 27419.8 |
