4KBZ

Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetylamino}-phenyl-acetic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0031418	molecular_function	L-ascorbic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 1QA A 501

Chain	Residue
A	VAL241
A	ARG322
A	TYR329
A	LEU343
A	HIS374
A	VAL376
A	ARG383
A	LYS408
A	FE2502
A	HOH624
A	HOH625
A	SER242
A	HOH633
A	ARG252
A	TRP258
A	MET299
A	TYR303
A	TYR310
A	HIS313
A	ASP315

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 502

Chain	Residue
A	HIS313
A	ASP315
A	HIS374
A	1QA501
A	HOH624

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	ARG396
A	ARG411
A	LYS416

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	HIS205
A	ARG370

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 505

Chain	Residue
A	GLU357
A	ARG362
A	HOH643

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	101
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Beta(2)beta(3) 'finger-like' loop","evidences":[{"source":"PubMed","id":"18063574","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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