4K4G
Ternary crystal structures of human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND L-DCTP.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I, M | DNA polymerase lambda | polymer | 340 | 38254.6 | 4 | UniProt (Q9UGP5) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) In PDB | Homo sapiens (human) | Pol Lambda, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa |
| 2 | B, F, J, N | DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3') | polymer | 11 | 3390.2 | 4 | Synthetic construct | ||
| 3 | C, G, K, O | DNA (5'-D(*CP*AP*GP*TP*AP*C)-3') | polymer | 6 | 1793.2 | 4 | Synthetic construct | ||
| 4 | D, H, L, P | DNA (5'-D(P*GP*CP*CP*G)-3') | polymer | 4 | 1191.8 | 4 | Synthetic construct | ||
| 5 | I, M, A, E | 4-amino-1-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-L-erythro-pentofuranosyl}pyrimidin-2(1H)-one | non-polymer | 467.2 | 4 | Chemie (1S0) | |||
| 6 | E, F, I, J, L... | CALCIUM ION | non-polymer | 40.1 | 22 | Chemie (CA) | |||
| 7 | F, I, M, B | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 8 | M | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 9 | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A, E, I, M: 245 - 575 (UniProt: Q9UGP5)
| PDB | External Database | Details |
|---|---|---|
| Met 244 | - | expression tag |
| Leu 576 | - | expression tag |
| Glu 577 | - | expression tag |
| His 578 | - | expression tag |
| His 579 | - | expression tag |
| His 580 | - | expression tag |
| His 581 | - | expression tag |
| His 582 | - | expression tag |
| His 583 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 178519.3 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 3123.5 | |
| All* | Total formula weight | 181642.8 |
