Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4K4G

Ternary crystal structures of human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND L-DCTP.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0006281	biological_process	DNA repair
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034061	molecular_function	DNA polymerase activity
I	0003677	molecular_function	DNA binding
I	0003887	molecular_function	DNA-directed DNA polymerase activity
I	0006281	biological_process	DNA repair
I	0016779	molecular_function	nucleotidyltransferase activity
I	0034061	molecular_function	DNA polymerase activity
M	0003677	molecular_function	DNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0006281	biological_process	DNA repair
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE 1S0 A 601

Chain	Residue
A	ARG386
A	PHE506
A	GLY508
A	ALA510
A	ASN513
A	CA602
A	CA603
A	HOH703
A	HOH707
A	HOH720
A	HOH723
A	GLY416
A	HOH738
A	HOH773
A	HOH786
B	DG5
C	DC6
C	HOH102
A	SER417
A	ARG420
A	CYS425
A	GLY426
A	ASP427
A	ASP429
A	TYR505

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 602

Chain	Residue
A	ASP427
A	ASP429
A	1S0601
A	HOH703

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 603

Chain	Residue
A	ASP427
A	ASP429
A	ASP490
A	1S0601
A	HOH707
C	DC6

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 604

Chain	Residue
A	SER339
A	ILE341
A	ALA344
A	HOH812
C	DA5
C	HOH101

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 605

Chain	Residue
A	CYS300
A	ILE302
A	ILE305
D	DC3

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 606

Chain	Residue
A	SER463
A	HOH797
B	HOH203
B	HOH210
B	HOH214
M	HOH771

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 101

Chain	Residue
B	HOH218
B	HOH219

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT B 102

Chain	Residue
B	DG2
B	DG3
N	DC1

site_id	AC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1S0 E 601

Chain	Residue
E	ARG386
E	GLY416
E	SER417
E	ARG420
E	GLY426
E	ASP427
E	ASP429
E	TYR505
E	PHE506
E	GLY508
E	ALA510
E	ASN513
E	CA602
E	CA603
E	CA605
E	HOH701
E	HOH736
E	HOH742
E	HOH745
F	DG5
G	DC6

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 602

Chain	Residue
E	ASP427
E	ASP429
E	1S0601
E	HOH701

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 603

Chain	Residue
E	ASP427
E	ASP429
E	ASP490
E	1S0601
E	HOH745
G	DC6

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 604

Chain	Residue
E	SER463
E	GLN470
E	LYS472
F	DC9

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA E 605

Chain	Residue
E	ALA510
E	1S0601
E	HOH742

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 606

Chain	Residue
G	HOH102
E	SER339
E	ILE341
E	ALA344
E	HOH729
G	DA5

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA F 101

Chain	Residue
F	HOH203
F	HOH205

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT F 102

Chain	Residue
F	DG2
H	DG4

site_id	BC8
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 1S0 I 601

Chain	Residue
I	ARG386
I	SER417
I	ARG420
I	GLY426
I	ASP427
I	ASP429
I	TYR505
I	PHE506
I	SER509
I	ALA510
I	ASN513
I	ARG514
I	ARG517
I	CA603
I	HOH720
I	HOH741
I	HOH750
J	DG5
K	DC6

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 602

Chain	Residue
I	ASP427
I	ASP429
I	ASP490
I	CA603
I	HOH719
I	HOH736

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA I 603

Chain	Residue
I	ASP427
I	ASP429
I	1S0601
I	CA602
I	HOH736
I	HOH741
I	HOH750

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 604

Chain	Residue
I	SER339
I	ILE341
I	ALA344
K	DA5
K	HOH102
K	HOH103

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT I 605

Chain	Residue
I	PRO554
I	THR555
I	GLU556

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA J 101

Chain	Residue
J	DC4
J	DG6

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA J 102

Chain	Residue
A	HOH701
J	HOH202
K	HOH101

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA L 101

Chain	Residue
I	ARG308
I	HOH766
L	DG1

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT M 601

Chain	Residue
M	GLU466
N	DC9

site_id	CC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 1S0 M 602

Chain	Residue
M	ARG386
M	SER417
M	ARG420
M	GLY426
M	ASP427
M	TYR505
M	PHE506
M	SER509
M	ALA510
M	ASN513
M	ARG517
M	CA603
M	HOH731
M	HOH791
N	DG5
O	DC6

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 603

Chain	Residue
M	ASP427
M	ASP429
M	1S0602
M	HOH791
M	HOH798

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA M 604

Chain	Residue
M	CYS300
M	ILE302
M	ILE305
P	DC3

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 605

Chain	Residue
M	SER339
M	ILE341
M	ALA344
O	DA5
O	HOH101

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 606

Chain	Residue
M	ASP427
M	ASP429
M	ASP490
M	HOH760
M	HOH798

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CAC M 607

Chain	Residue
M	GLU318
M	GLU318

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269\|PubMed:11457865

Chain	Residue	Details
A	LYS312
E	LYS312
I	LYS312
M	LYS312

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17475573, ECO:0007744\|PDB:2PFP, ECO:0007744\|PDB:2PFQ

Chain	Residue	Details
A	ARG386
I	SER417
I	GLY426
I	ASN513
M	ARG386
M	SER417
M	GLY426
M	ASN513
A	SER417
A	GLY426
A	ASN513
E	ARG386
E	SER417
E	GLY426
E	ASN513
I	ARG386

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:17475573, ECO:0007744\|PDB:2PFO, ECO:0007744\|PDB:2PFQ

Chain	Residue	Details
A	ASP427
M	ASP427
M	ASP429
M	ASP490
A	ASP429
A	ASP490
E	ASP427
E	ASP429
E	ASP490
I	ASP427
I	ASP429
I	ASP490

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)