4K12

Structural Basis for Host Specificity of Factor H Binding by Streptococcus pneumoniae

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Complement factor H	polymer	64	7271.0	1	UniProt (P08603) Pfam (PF00084)	Homo sapiens (human)	Factor H protein, H factor 1
2	B (B)	Choline binding protein A	polymer	84	9737.1	1	UniProt (G6W2B2)	Streptococcus pneumoniae	CbpA
3	C, D (A, B)	water	water		18.0	255	Chemie (HOH)

Sequence modifications

A: 4 - 63 (UniProt: P08603)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 1	-	expression tag
His 2	-	expression tag
Met 3	-	expression tag

B: 2 - 82 (UniProt: G6W2B2)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag
Met 1	-	expression tag
Glu 61	Gln 127	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	17008.0
All*	Total formula weight	17008.0

*Water molecules are not included.