4IY5
Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glutamate receptor 2 | polymer | 263 | 29244.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (rat brown rat rats) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 |
2 | A, B | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | A, B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
5 | A, B | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
6 | B | piperidin-1-yl(quinoxalin-6-yl)methanone | non-polymer | 241.3 | 1 | Chemie (CX5) | |||
7 | water | water | 18.0 | 572 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 117 (UniProt: P19491)
A, B: 120 - 263 (UniProt: P19491)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ala 2 | - | expression tag |
Tyr 94 | Leu 504 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 118 | - | linker |
Thr 119 | - | linker |
Ser 242 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58489.4 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 1398.5 | |
All* | Total formula weight | 59887.9 |