4IY5

Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 301

Chain	Residue
A	TYR61
A	TYR220
A	HOH402
A	HOH403
A	HOH427
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH419
A	HOH429
A	HOH512

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 303

Chain	Residue
A	ARG148
A	TRP159
A	ARG163

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	LYS82
A	LYS116
A	HOH442
A	HOH684

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 305

Chain	Residue
A	LYS4
A	THR5

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CX5 B 301

Chain	Residue
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER217
A	LYS218
A	GLY219
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
B	HOH436
B	HOH508

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU B 302

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	HOH402
B	HOH412
B	HOH445

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
A	LYS183
B	ARG31
B	HOH429
B	HOH432
B	HOH588
B	HOH594

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 304

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	HOH441
B	HOH497
B	HOH657

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 305

Chain	Residue
B	ARG148
B	TRP159
B	ARG163

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 306

Chain	Residue
B	SER194
B	THR195
B	GLU198
B	ASN214
B	HOH589

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 307

Chain	Residue
A	HOH536
B	LYS21
B	ASN22
B	HIS23
B	HOH409
B	HOH578

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 308

Chain	Residue
B	GLN244

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 309

Chain	Residue
B	ARG163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3

---