4IRU
Crystal Structure of lepB GAP core in a transition state mimetic complex with Rab1A and ALF3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | LepB | polymer | 299 | 33916.3 | 3 | UniProt (Q5ZSM7) Pfam (PF18172) Pfam (PF18227) | Legionella pneumophila | |
| 2 | B, D, F (B, D, F) | Ras-related protein Rab-1A | polymer | 184 | 21175.2 | 3 | UniProt (P62820) Pfam (PF00071) | Homo sapiens (human) | YPT1-related protein |
| 3 | AA, BA, CA, DA, EA... (C, A, D, B) | ACETATE ION | non-polymer | 59.0 | 12 | Chemie (ACT) | |||
| 4 | FA, I, J, K, L... (C, A, B) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | GA, O, P, Q, R... (C, A, B) | POTASSIUM ION | non-polymer | 39.1 | 6 | Chemie (K) | |||
| 6 | HA, MA, S (D, F, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 7 | IA, NA, T (D, F, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
| 8 | JA, OA, U (D, F, B) | ALUMINUM FLUORIDE | non-polymer | 84.0 | 3 | Chemie (AF3) | |||
| 9 | PA, QA, RA, SA, TA (A, B, C, D, F) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A, C, E: 326 - 623 (UniProt: Q5ZSM7)
B, D, F: 4 - 177 (UniProt: P62820)
| PDB | External Database | Details |
|---|---|---|
| Ser 325 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Mse -6 | - | expression tag |
| Gly -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 165274.4 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 3334.3 | |
| All* | Total formula weight | 168608.8 |
