4HW5

Crystal Structure of the Human C3a anaphylatoxin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Complement C3	polymer	83	9499.1	2	UniProt (P01024) Pfam (PF01821) In PDB	Homo sapiens (human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, Complement C3 beta chain, Complement C3 alpha chain, C3a anaphylatoxin, Acylation stimulating protein, ASP, C3adesArg, Complement C3b alpha' chain, Complement C3c alpha' chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C3c alpha' chain fragment 2
2	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3		water	water		18.0	34	Chemie (HOH)

Sequence modifications

A, B: 672 - 748 (UniProt: P01024)

PDB	External Database	Details
Gly 666	-	expression tag
Ala 667	-	expression tag
Gly 668	-	expression tag
Ala 669	-	expression tag
Ala 670	-	expression tag
Gly 671	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	18998.2
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	19190.4

*Water molecules are not included.