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4HW5

Crystal Structure of the Human C3a anaphylatoxin

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0006954biological_processinflammatory response
A0006956biological_processcomplement activation
B0005576cellular_componentextracellular region
B0006954biological_processinflammatory response
B0006956biological_processcomplement activation
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 801
ChainResidue
AARG704
BASN701
BTHR732
BARG735
BHOH908

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 801
ChainResidue
AASN701
ATHR732
AHOH906
BARG704

Functional Information from PROSITE/UniProt
site_idPS01177
Number of Residues36
DetailsANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCedGmrenpmrfSCQrrtrfisl.GeaCkkvfld.CC
ChainResidueDetails
ACYS693-CYS728

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by carboxypeptidases
ChainResidueDetails
AALA747
BALA747

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by C3 convertase
ChainResidueDetails
AARG748
BARG748

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
ASER672
BSER672

227111

PDB entries from 2024-11-06

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