4HNE

Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Phosphatidylinositol 4-kinase type 2-alpha	polymer	384	43824.9	2	UniProt (Q9BTU6) Pfam (PF00454) In PDB	Homo sapiens (human)	Phosphatidylinositol 4-kinase type II-alpha
2	A, B	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
3		water	water		18.0	40	Chemie (HOH)

Sequence modifications

A, B: 78 - 453 (UniProt: Q9BTU6)

PDB	External Database	Details
Gly 70	-	expression tag
Pro 71	-	expression tag
Leu 72	-	expression tag
Gly 73	-	expression tag
Ser 74	-	expression tag
Pro 75	-	expression tag
Glu 76	-	expression tag
Phe 77	-	expression tag
Ser 174	Cys 174	engineered mutation
Ser 175	Cys 175	engineered mutation
Ser 177	Cys 177	engineered mutation
Ser 178	Cys 178	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87649.8
Non-Polymers*	Number of molecules	2
	Total formula weight	854.4
All*	Total formula weight	88504.2

*Water molecules are not included.