4HNE

Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004430	molecular_function	1-phosphatidylinositol 4-kinase activity
B	0004430	molecular_function	1-phosphatidylinositol 4-kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP A 500

Chain	Residue
A	GLY133
A	ILE345
A	ASP346
A	HOH607
A	SER134
A	SER137
A	PHE139
A	LYS152
A	GLN261
A	LEU262
A	PHE263
A	VAL264

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ADP B 500

Chain	Residue
B	TYR131
B	LYS152
B	GLN261
B	LEU262
B	PHE263
B	VAL264
B	ASP346
B	HOH608

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Region: {"description":"Important for substrate binding","evidences":[{"source":"PubMed","id":"24675427","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	34
Details	Region: {"description":"Important for interaction with membranes","evidences":[{"source":"PubMed","id":"24675427","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24675427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25168678","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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