4HNA
Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tubulin alpha chain | polymer | 451 | 50204.4 | 1 | UniProt (D0VWZ0) Pfam (PF00091) Pfam (PF03953) | Ovis aries (domestic sheep lambs wild sheep) | |
| 2 | B (B) | Tubulin beta chain | polymer | 445 | 49983.8 | 1 | UniProt (D0VWY9) Pfam (PF00091) Pfam (PF03953) | Ovis aries (domestic sheep lambs wild sheep) | |
| 3 | C (D) | DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D2 | polymer | 169 | 18140.3 | 1 | ARTIFICIAL GENE | ||
| 4 | D (K) | Kinesin-1 heavy chain | polymer | 349 | 39174.0 | 1 | UniProt (P33176) Pfam (PF00225) | Homo sapiens (human) | Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC |
| 5 | E (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 6 | F, H, K (A, B, K) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 7 | G (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 8 | I, L (B, K) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) | |||
| 9 | J (K) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 10 | M (K) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 1 - 451 (UniProt: D0VWZ0)
B: 1 - 455 (UniProt: D0VWY9)
K: 1 - 349 (UniProt: P33176)
| PDB | External Database | Details |
|---|---|---|
| Ser 232 | Gly 232 | SEE REMARK 999 |
| Ser 340 | Thr 340 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Ile 318 | Val 316 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Ser 7 | Cys 7 | SEE REMARK 999 |
| Ala 65 | Cys 65 | SEE REMARK 999 |
| Ala 168 | Cys 168 | SEE REMARK 999 |
| Ser 174 | Cys 174 | SEE REMARK 999 |
| Ala 294 | Cys 294 | SEE REMARK 999 |
| Ser 330 | Cys 330 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 157502.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1672.4 | |
| All* | Total formula weight | 159175.1 |
