4HKA

Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tryptophan 2,3-dioxygenase	polymer	366	43361.7	1	UniProt (P20351) Pfam (PF03301) In PDB	Drosophila melanogaster (Fruit fly)	TDO, Protein vermilion, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase
2	A	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
3		water	water		18.0	24	Chemie (HOH)

Sequence modifications

A: 24 - 379 (UniProt: P20351)

PDB	External Database	Details
Met 22	-	expression tag
Gly 23	-	expression tag
Leu 380	-	expression tag
Glu 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43361.7
Non-Polymers*	Number of molecules	1
	Total formula weight	616.5
All*	Total formula weight	43978.2

*Water molecules are not included.