4HKA
Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
| A | 0005575 | cellular_component | cellular_component |
| A | 0006569 | biological_process | tryptophan catabolic process |
| A | 0006727 | biological_process | ommochrome biosynthetic process |
| A | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
| A | 0019442 | biological_process | tryptophan catabolic process to acetyl-CoA |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048072 | biological_process | compound eye pigmentation |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0070189 | biological_process | kynurenine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEM A 401 |
| Chain | Residue |
| A | TYR27 |
| A | GLN138 |
| A | PHE142 |
| A | TYR159 |
| A | ASN160 |
| A | TRP308 |
| A | ARG309 |
| A | HIS312 |
| A | MET315 |
| A | VAL316 |
| A | MET319 |
| A | PHE57 |
| A | TYR335 |
| A | LEU336 |
| A | HOH521 |
| A | HIS61 |
| A | TYR64 |
| A | PHE68 |
| A | LEU116 |
| A | PHE124 |
| A | ALA134 |
| A | PHE137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03020 |
| Chain | Residue | Details |
| A | PHE57 | |
| A | ARG128 | |
| A | THR327 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:23333332, ECO:0007744|PDB:4HKA |
| Chain | Residue | Details |
| A | HIS312 |
