4HD0

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	DNA double-strand break repair protein Mre11	polymer	339	39801.5	2	UniProt (Q8U1N9) Pfam (PF00149) Pfam (PF22411) In PDB	Pyrococcus furiosus	pfMre11
2	A, B	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
3		water	water		18.0	64	Chemie (HOH)

Sequence modifications

A, B: 1 - 333 (UniProt: Q8U1N9)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Arg 204	Leu 204	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79603.0
Non-Polymers*	Number of molecules	4
	Total formula weight	219.8
All*	Total formula weight	79822.7

*Water molecules are not included.