4H34

Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein phosphatase non-receptor type 11	polymer	560	64408.6	1	UniProt (Q06124) Pfam (PF00017) Pfam (PF00102)	Homo sapiens (human)	Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3
2	B, C, D, F, G... (A)	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
3	E, I (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	J (A)	water	water		18.0	54	Chemie (HOH)

Sequence modifications

A: 1 - 539 (UniProt: Q06124)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
-	Gln 408	deletion
-	Ala 409	deletion
-	Leu 410	deletion
-	Leu 411	deletion
Pro 506	Gln 510	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	64408.6
Non-Polymers*	Number of molecules	8
	Total formula weight	556.6
All*	Total formula weight	64965.2

*Water molecules are not included.