4H25
TCR interaction with peptide mimics of nickel offers structure insights to nickel contact allergy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 180 | 20913.6 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B, E (B, E) | MHC class II antigen | polymer | 188 | 21936.6 | 2 | UniProt (B8YAC7) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C, F (C, F) | peptide | polymer | 22 | 2490.0 | 2 | |||
| 4 | G, H, I, J, K... (G, H, I, J, K...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 5 | M, N, O, P (A, B, E) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 4 | Chemie (IPA) | |||
| 6 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
B, E: 6 - 188 (UniProt: B8YAC7)
| PDB | External Database | Details |
|---|---|---|
| Thr 3 | - | expression tag |
| Arg 4 | - | expression tag |
| Pro 5 | - | expression tag |
| Thr 77 | Asn 72 | conflict |
| Arg 189 | - | expression tag |
| Ala 190 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 90680.3 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2546.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 240.4 | |
| All* | Total formula weight | 93467.1 |
