4FL3
Structural and Biophysical Characterization of the Syk Activation Switch
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase SYK | polymer | 635 | 72133.2 | 1 | UniProt (P43405) Pfam (PF00017) Pfam (PF07714) In PDB | Homo sapiens (human) | Spleen tyrosine kinase, p72-Syk |
| 2 | A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 405 | Chemie (HOH) |
Sequence modifications
A: 1 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Phe 348 | Tyr 348 | engineered mutation |
| Phe 352 | Tyr 352 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 72133.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 530.5 | |
| All* | Total formula weight | 72663.7 |
