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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4FL3

Structural and Biophysical Characterization of the Syk Activation Switch

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001525biological_processangiogenesis
A0001775biological_processcell activation
A0001784molecular_functionphosphotyrosine residue binding
A0001819biological_processpositive regulation of cytokine production
A0001820biological_processserotonin secretion
A0001945biological_processlymph vessel development
A0002092biological_processpositive regulation of receptor internalization
A0002223biological_processstimulatory C-type lectin receptor signaling pathway
A0002250biological_processadaptive immune response
A0002281biological_processmacrophage activation involved in immune response
A0002283biological_processneutrophil activation involved in immune response
A0002366biological_processleukocyte activation involved in immune response
A0002376biological_processimmune system process
A0002554biological_processserotonin secretion by platelet
A0002752biological_processcell surface pattern recognition receptor signaling pathway
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005102molecular_functionsignaling receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0006606biological_processprotein import into nucleus
A0007159biological_processleukocyte cell-cell adhesion
A0007166biological_processcell surface receptor signaling pathway
A0007167biological_processenzyme-linked receptor protein signaling pathway
A0007229biological_processintegrin-mediated signaling pathway
A0009887biological_processanimal organ morphogenesis
A0010543biological_processregulation of platelet activation
A0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
A0016170molecular_functioninterleukin-15 receptor binding
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0018108biological_processpeptidyl-tyrosine phosphorylation
A0019370biological_processleukotriene biosynthetic process
A0019722biological_processcalcium-mediated signaling
A0019815cellular_componentB cell receptor complex
A0019901molecular_functionprotein kinase binding
A0019902molecular_functionphosphatase binding
A0030168biological_processplatelet activation
A0030183biological_processB cell differentiation
A0030593biological_processneutrophil chemotaxis
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031623biological_processreceptor internalization
A0032009cellular_componentearly phagosome
A0032481biological_processpositive regulation of type I interferon production
A0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
A0032733biological_processpositive regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0032752biological_processpositive regulation of interleukin-3 production
A0032753biological_processpositive regulation of interleukin-4 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032765biological_processpositive regulation of mast cell cytokine production
A0032928biological_processregulation of superoxide anion generation
A0032930biological_processpositive regulation of superoxide anion generation
A0032991cellular_componentprotein-containing complex
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0035325molecular_functionToll-like receptor binding
A0035556biological_processintracellular signal transduction
A0038063biological_processcollagen-activated tyrosine kinase receptor signaling pathway
A0038095biological_processFc-epsilon receptor signaling pathway
A0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
A0038156biological_processinterleukin-3-mediated signaling pathway
A0042101cellular_componentT cell receptor complex
A0042169molecular_functionSH2 domain binding
A0042492biological_processgamma-delta T cell differentiation
A0042742biological_processdefense response to bacterium
A0043274molecular_functionphospholipase binding
A0043303biological_processmast cell degranulation
A0043306biological_processpositive regulation of mast cell degranulation
A0043313biological_processregulation of neutrophil degranulation
A0043366biological_processbeta selection
A0043410biological_processpositive regulation of MAPK cascade
A0045087biological_processinnate immune response
A0045579biological_processpositive regulation of B cell differentiation
A0045588biological_processpositive regulation of gamma-delta T cell differentiation
A0045621biological_processpositive regulation of lymphocyte differentiation
A0045780biological_processpositive regulation of bone resorption
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0046641biological_processpositive regulation of alpha-beta T cell proliferation
A0048514biological_processblood vessel morphogenesis
A0050764biological_processregulation of phagocytosis
A0050776biological_processregulation of immune response
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050853biological_processB cell receptor signaling pathway
A0050900biological_processleukocyte migration
A0051090biological_processregulation of DNA-binding transcription factor activity
A0051649biological_processestablishment of localization in cell
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0071226biological_processcellular response to molecule of fungal origin
A0071396biological_processcellular response to lipid
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
A0090237biological_processregulation of arachidonate secretion
A0090330biological_processregulation of platelet aggregation
A0097110molecular_functionscaffold protein binding
A0097190biological_processapoptotic signaling pathway
A0097242biological_processamyloid-beta clearance
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1904263biological_processpositive regulation of TORC1 signaling
A1904646biological_processcellular response to amyloid-beta
A1990858biological_processcellular response to lectin
Functional Information from PDB Data
site_idAC1
Number of Residues26
DetailsBINDING SITE FOR RESIDUE ANP A 701
ChainResidue
ASER379
AMET450
AALA451
APRO455
ALYS458
AARG498
AASN499
ALEU501
AASP512
AMG702
AHOH921
AGLY380
AHOH927
AHOH954
AHOH1013
AHOH1116
AHOH1149
AHOH1172
AHOH1198
AASN381
AGLY383
AVAL385
AALA400
ALYS402
AVAL433
AGLU449
site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 702
ChainResidue
AASN499
AASP512
AANP701
AHOH1002
AHOH1198
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues26
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGNFGTVKkGyyqmkkvvkt........VAVK
ChainResidueDetails
ALEU377-LYS402
site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNVLL
ChainResidueDetails
APHE490-LEU502
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues92
DetailsDomain: {"description":"SH2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues91
DetailsDomain: {"description":"SH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues59
DetailsRegion: {"description":"Interdomain A"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues5
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues9
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P48025","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18369315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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