4F2A
Crystal structure of cholestryl esters transfer protein in complex with inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cholesteryl ester transfer protein | polymer | 476 | 53097.8 | 1 | UniProt (P11597) Pfam (PF01273) Pfam (PF02886) In PDB | Homo sapiens (human) | Lipid transfer protein I |
2 | B | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G47477HI) | |||
3 | A | CHOLESTERYL OLEATE | non-polymer | 651.1 | 2 | Chemie (2OB) | |||
4 | A | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 1 | Chemie (PCW) | |||
5 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
6 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
7 | A | (2R)-3-{[4-(4-chloro-3-ethylphenoxy)pyrimidin-2-yl][3-(1,1,2,2-tetrafluoroethoxy)benzyl]amino}-1,1,1-trifluoropropan-2-ol | non-polymer | 567.9 | 1 | Chemie (0SF) |
Sequence modifications
A: 1 - 476 (UniProt: P11597)
PDB | External Database | Details |
---|---|---|
Ala 1 | Cys 18 | engineered mutation |
Asp 88 | Asn 105 | engineered mutation |
Ala 131 | Cys 148 | engineered mutation |
Asp 240 | Asn 257 | engineered mutation |
Asp 341 | Asn 358 | engineered mutation |
Ile 405 | Val 422 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 53097.8 | |
Branched | Number of molecules | 1 |
Total formula weight | 732.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2842.8 | |
All* | Total formula weight | 56673.3 |