4EUW

Crystal structure of a HMG domain of transcription factor SOX-9 bound to DNA (SOX-9/DNA) from Homo sapiens at 2.77 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Transcription factor SOX-9	polymer	106	12917.7	1	UniProt (P48436) Pfam (PF00505)	Homo sapiens (human)
2	B (B)	DNA (5'-D(*CP*TP*CP*TP*TP*TP*GP*AP*GP*AP*AP*G)-3')	polymer	12	3677.4	1		Homo sapiens
3	C (C)	DNA (5'-D(*CP*TP*TP*CP*TP*CP*AP*AP*AP*GP*AP*G)-3')	polymer	12	3646.4	1		Homo sapiens
4	D, E (A, B)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

A: 98 - 181 (UniProt: P48436)

PDB	External Database	Details
Met -21	-	expression tag
Ala -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Val -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Met -7	-	expression tag
Ser -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	20241.5
All*	Total formula weight	20241.5

*Water molecules are not included.