4EJ8
Apo HIV Protease (PR) dimer in closed form with fragment 1F1 in the outside/top of flap
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protease | polymer | 99 | 10767.7 | 2 | UniProt (P12499) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | PR, Retropepsin |
2 | A, B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 5 | Chemie (DMS) | |||
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | A | 1H-indole-6-carboxylic acid | non-polymer | 161.2 | 1 | Chemie (1F1) | |||
5 | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P12499)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 496 | engineered mutation |
Ile 33 | Leu 522 | engineered mutation |
Arg 41 | Lys 530 | conflict |
Ile 63 | Leu 552 | engineered mutation |
Ala 67 | Cys 556 | engineered mutation |
Ala 95 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21535.4 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 800.1 | |
All* | Total formula weight | 22335.5 |