Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 101 |
| Chain | Residue |
| A | LYS70 |
| B | LYS43 |
| B | LYS45 |
| B | GLN58 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 102 |
| Chain | Residue |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | HOH247 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 103 |
| Chain | Residue |
| A | ARG87 |
| A | THR91 |
| A | EDO105 |
| A | HOH218 |
| B | LEU5 |
| B | TRP6 |
| A | LEU19 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 104 |
| Chain | Residue |
| A | GLU34 |
| A | GLU35 |
| A | GLY78 |
| A | PRO79 |
| A | THR80 |
| B | TRP42 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 105 |
| Chain | Residue |
| A | LEU19 |
| A | ASN88 |
| A | GLN92 |
| A | DMS103 |
| A | HOH248 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1F1 A 106 |
| Chain | Residue |
| A | TRP42 |
| A | PRO44 |
| A | LYS45 |
| A | LYS55 |
| A | VAL56 |
| A | ARG57 |
| A | THR91 |
| A | GLN92 |
| A | GLY94 |
| A | HOH205 |
| A | HOH221 |
| B | TRP6 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS B 101 |
| Chain | Residue |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS B 102 |
| Chain | Residue |
| A | GLU65 |
| A | GLY68 |
| A | HOH223 |
| B | ARG41 |
| B | TRP42 |
| B | LYS43 |
| B | GLN58 |
| B | ASP60 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 103 |
| Chain | Residue |
| B | ASP30 |
| B | GLN58 |
| B | HOH250 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 104 |
| Chain | Residue |
| A | LEU19 |
| B | PRO39 |
| B | GLY40 |
| B | ARG41 |
| B | HOH206 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
