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4EE3

Crystal structure of human M340H-beta-1,4-galactosyltransferase-1 (M340H-B4GAL-T1) in complex with pentasaccharide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, CBeta-1,4-galactosyltransferase 1polymer28732773.23UniProt (P15291)
Pfam (PF13733)
Pfam (PF02709)
In PDB
Homo sapiens (human)Beta-1,4-GalTase 1, Beta4Gal-T1, b4Gal-T1, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1, Lactose synthase A protein, N-acetyllactosamine synthase, Nal synthase, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase, Processed beta-1,4-galactosyltransferase 1
2D, E, Fbeta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranosebranched910.83In PDB
GlyTouCan (G33889GK)
3C, A, B6-AMINOHEXYL-URIDINE-C1,5'-DIPHOSPHATEnon-polymer503.33Chemie (UDH)
4C, A, BMANGANESE (II) IONnon-polymer54.93Chemie (MN)
5C, A, BSULFATE IONnon-polymer96.118Chemie (SO4)
6C, A, BGLYCEROLnon-polymer92.13Chemie (GOL)
7waterwater18.0527Chemie (HOH)
Sequence modifications
A, B, C: 126 - 398 (UniProt: P15291)
PDBExternal DatabaseDetails
Ala 112-expression tag
Ser 113-expression tag
Met 114-expression tag
Thr 115-expression tag
Gly 116-expression tag
Gly 117-expression tag
Gln 118-expression tag
Gln 119-expression tag
Met 120-expression tag
Gly 121-expression tag
Arg 122-expression tag
Gly 123-expression tag
Ser 124-expression tag
Ala 125-expression tag
Thr 337Arg 337engineered mutation
Thr 338Cys 338engineered mutation
His 340Met 340engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight98319.7
BranchedNumber of molecules3
Total formula weight2732.5
Non-Polymers*Number of molecules27
Total formula weight3680.2
All*Total formula weight104732.4
*Water molecules are not included.

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PDB entries from 2024-03-27

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