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4E43

HIV protease (PR) dimer with acetate in exo site and peptide in active site

Replaces:  3KF1
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Proteasepolymer9910831.82UniProt (Q903N5)
Pfam (PF00077)
UniProt (by SIFTS) (P12499)
Human immunodeficiency virus 1
2C
(C)
Random peptidepolymer6744.91unidentified
3D, E, K, L
(A, B)
DIMETHYL SULFOXIDEnon-polymer78.14Chemie (DMS)
4F
(A)
ACETATE IONnon-polymer59.01Chemie (ACT)
5G, H, I, J, N...
(A, B)
GLYCEROLnon-polymer92.110Chemie (GOL)
6M
(B)
BETA-MERCAPTOETHANOLnon-polymer78.11Chemie (BME)
7T, U, V
(A, B, C)
waterwater18.0188Chemie (HOH)
Sequence modifications
A, B: 1 - 99 (UniProt: Q903N5)
PDBExternal DatabaseDetails
Lys 7Arg 7engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight22408.6
Non-Polymers*Number of molecules16
Total formula weight1370.6
All*Total formula weight23779.2
*Water molecules are not included.

237992

PDB entries from 2025-06-25

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