4E41
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F | HLA class II histocompatibility antigen, DR alpha chain | polymer | 182 | 21155.9 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) In PDB | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B, G | HLA class II histocompatibility antigen, DRB1-1 beta chain | polymer | 190 | 22080.7 | 2 | UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) In PDB | Homo sapiens (human) | MHC class II antigen DRB1*1, DR-1, DR1 |
| 3 | C, H | Triosephosphate isomerase | polymer | 15 | 1481.7 | 2 | UniProt (P60174) In PDB | Homo sapiens (human) | TIM, Triose-phosphate isomerase |
| 4 | D, I | T cell receptor G4 alpha chain | polymer | 203 | 22671.0 | 2 | Homo sapiens | ||
| 5 | E, J | T cell receptor G4 beta chain | polymer | 239 | 27154.2 | 2 | Homo sapiens | ||
| 6 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
C, H: 23 - 37 (UniProt: P60174)
| PDB | External Database | Details |
|---|---|---|
| Ile 28 | Thr 65 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 189086.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 46.0 | |
| All* | Total formula weight | 189132.8 |
