4E41
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| A | 0019882 | biological_process | antigen processing and presentation |
| A | 0042613 | cellular_component | MHC class II protein complex |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| B | 0019882 | biological_process | antigen processing and presentation |
| B | 0042613 | cellular_component | MHC class II protein complex |
| F | 0006955 | biological_process | immune response |
| F | 0016020 | cellular_component | membrane |
| F | 0019882 | biological_process | antigen processing and presentation |
| F | 0042613 | cellular_component | MHC class II protein complex |
| G | 0006955 | biological_process | immune response |
| G | 0016020 | cellular_component | membrane |
| G | 0019882 | biological_process | antigen processing and presentation |
| G | 0042613 | cellular_component | MHC class II protein complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 201 |
| Chain | Residue |
| A | GLU98 |
| A | GLU101 |
| G | THR185 |
| G | GLU187 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 201 |
| Chain | Residue |
| B | THR185 |
| F | GLU98 |
| F | GLU101 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH |
| Chain | Residue | Details |
| B | TYR171-HIS177 | |
| A | TYR161-HIS167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P17751 |
| Chain | Residue | Details |
| C | ALA31 | |
| H | ALA31 | |
| B | HIS81 | |
| B | ASN82 | |
| G | ASP57 | |
| G | TRP61 | |
| G | HIS81 | |
| G | ASN82 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8145819 |
| Chain | Residue | Details |
| B | ARG93 | |
| G | ARG93 | |
| F | GLY49 | |
| F | ALA52 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431 |
| Chain | Residue | Details |
| B | ASN19 | |
| G | ASN19 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 |
| Chain | Residue | Details |
| A | SER53 | |
| F | SER53 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | GLU55 | |
| F | GLU55 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ASN62 | |
| F | ASN62 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ASN69 | |
| F | ASN69 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ARG76 | |
| F | ARG76 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 |
| Chain | Residue | Details |
| A | ASN78 | |
| A | ASN118 | |
| F | ASN78 | |
| F | ASN118 |
